The most popular artist of the 20th century, a student of N. Lytras, a follower of Kontoglou and an admirer of the Flemish art, he painted subjects and faces of the familiar daily life in the midst of a changing Athens and Greece. The old house turning into a building site of the "modernized" Athens, the furniture of another era being destroyed, the old habits that were disappearing, all this fascination with the commonplace which recalls images of Flemish art, were figures scattered on his canvases.

He is the artist who turned the visual ethography into a unique urban genre, incorporating the problems and worries of the modern era. This is the reason why he became "papa-Spyros", the artist who recorded in our memory the fading images of the humble, the trivial every-day objects that were dying, as Greece was becoming western.

In 1930, he was commissioned the decoration of the church of St. Dionisios Areopagitis, patron saint of Athens, a project that was often criticized for the introduction of secular elements in religious art. In the 1960s and 1970s he became the most prolific artist in Greece.